Title

Nitroxyl (azanone) trapping by metalloporphyrins

Document Type

Article

Publication Date

12-1-2011

Abstract

The present review starts describing nitroxyl (azanone, HNO) biological relevance, in relation with NO physiology, from a chemical reactivity perspective. After a description of commonly used azanone donors and their characteristics, the overlapping molecular targets of HNO and NO are presented with an emphasis on heme models and proteins. We present also a brief description of metalloporphyrins and the main characteristics of their nitrosyl complexes, and then describe the reactivity of azanone towards Fe, Ru, Mn and Co porphyrins, briefly mentioning heme proteins, and focusing on HNO trapping and its discrimination from NO. A comparison of reaction kinetics and/or nitrosyl product stability with non-heme models is also described. We illustrate the promiscuity of iron porphyrins, the stabilization properties of Ru and the discriminating behavior of Mn and Co porphyrins, which allows the design of optical and electrochemical selective HNO sensors. Finally, a comparative analysis and future perspectives are presented, focusing on the in vivo reactivity of azanone and its putative endogenous production. © 2011 Elsevier B.V. 1 1 1

Publication Name

Coordination Chemistry Reviews

Volume Number

255

First Page

2764

Last Page

2784

Issue Number

23-24

DOI

10.1016/j.ccr.2011.04.012

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