Title

Genome-wide approaches to monitor pre-mrna splicing

Document Type

Article

Publication Date

1-1-2010

Abstract

Pre-mRNA processing is an essential control-point in the gene expression pathway of eukaryotic organisms. The budding yeast Saccharomyces cerevisiae offers a powerful opportunity to examine the regulation of this pathway. In this chapter, we will describe methods that have been developed in our lab and others to examine pre-mRNA splicing from a genome-wide perspective in yeast. Our goal is to provide all of the necessary information-from microarray design to experimental setup to data analysis-to facilitate the widespread use of this technology. © 2010 Elsevier Inc. All rights reserved.

Publication Name

Methods in Enzymology

Volume Number

470

First Page

51

Last Page

75

Issue Number

C

DOI

10.1016/S0076-6879(10)70003-3

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