Title

Preparation of chiral isoxazole carbinols via catalytic asymmetric Corey-Bakshi-Shibata reduction

Document Type

Article

Publication Date

1-1-2010

Abstract

A diverse set of isoxazoles, with activity in three different disease categories, was reduced asymmetrically from pro-chiral ketones to chiral alcohols using the Corey-Bakshi-Shibata methodology at the α, β, and γ positions relative to the C-5-methyl of the isoxazole. The experiments described provide an easy route to hydroxylated isoxazoles that represent the common CYP-450 3A4 metabolic site.

Publication Name

Arkivoc

Volume Number

2010

First Page

97

Last Page

107

Issue Number

8

DOI

10.3998/ark.5550190.0011.809

This document is currently not available here.

Share

COinS