The role of an internal-return mechanism on measured isotope effects
This chapter considers interpretation of the magnitude of experimental primary kinetic isotope effects (PKIEs) associated with alcholic alkoxide-promoted dehydrohalogenation reactions. The existence of a heavy isotope of hydrogen was first suggested around 1930 and by 1933 Lewis and Macdonald1 obtained a sample of water consisting of about 65% deuterium by electrolysis. Lewis, in a communication to the editor2 prior to reporting their experimental results, made the statement: The separation of any isotope in sufficient quantity to permit investigation not only of its spectroscopic but also of its other chemical and physical properties suggests a wide range of interesting experiments but the isotope of hydrogen is, beyond all others, interesting to chemists. I believe that it will be so different from common hydrogen that it will be regarded almost as a new element. If this is true the organic chemistry of compounds containing the heavy isotope of hydrogen will be a fascinating study.
Isotope Effects in Chemistry and Biology
Koch, Heinz F., "The role of an internal-return mechanism on measured isotope effects" (2005). Faculty Articles Indexed in Scopus. 1963.