Title

The role of an internal-return mechanism on measured isotope effects

Document Type

Article

Publication Date

1-1-2005

Abstract

This chapter considers interpretation of the magnitude of experimental primary kinetic isotope effects (PKIEs) associated with alcholic alkoxide-promoted dehydrohalogenation reactions. The existence of a heavy isotope of hydrogen was first suggested around 1930 and by 1933 Lewis and Macdonald1 obtained a sample of water consisting of about 65% deuterium by electrolysis. Lewis, in a communication to the editor2 prior to reporting their experimental results, made the statement: The separation of any isotope in sufficient quantity to permit investigation not only of its spectroscopic but also of its other chemical and physical properties suggests a wide range of interesting experiments but the isotope of hydrogen is, beyond all others, interesting to chemists. I believe that it will be so different from common hydrogen that it will be regarded almost as a new element. If this is true the organic chemistry of compounds containing the heavy isotope of hydrogen will be a fascinating study.

Publication Name

Isotope Effects in Chemistry and Biology

First Page

465

Last Page

474

DOI

10.1201/9781420028027

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