Development of novel ultrafast-laser-based micro-CT system for small-animal imaging
We investigated the performance of an ultrafast-laser-based x-ray source as a possible replacement of a microfocal X-ray tube in a micro-CT system for small-animal imaging. Using a number of solid targets (Ge, Mo, Ag, Sn, BaF , La, and Nd) with matching filters, we optimized conditions for x-ray generation and measured x-ray spectra, conversion efficiency, x-ray fluence, and x-ray focal-spot size. We obtained images of small animals. X-ray spectra created by ultrafast laser are advantageous for micro-CT imaging because most of the emission is in narrow characteristic lines. The spectra could be rapidly changed and matched to the imaging task (e.g. animal thickness and density). This novel x-ray source can be also easily applied in dual-energy micro-CT for small-animal imaging with suitable contrast agent (e.g. I-, Ba-, or Gd-based) and matching targets and filters for low- and high-energy beams. We have established that the effective x-ray focal-spot size can be smaller than 5 μm and that the average power can surpass the power delivered by a microfocal x-ray tube with 5 fun focal-spot size. 2
IEEE Nuclear Science Symposium Conference Record
Krol, Andrzej; Kieffer, Jean Claude; Nees, John A.; Chen, Liming; Toth, Remy; Hou, Bixhue; Kincaid, Russell E.; Coman, Ioana L.; Chamberlain, Charles C.; Lipson, Edward D.; and Mourou, Gérard A., "Development of novel ultrafast-laser-based micro-CT system for small-animal imaging" (2003). Faculty Articles Indexed in Scopus. 2132.