Title

The effects of exercise training on resting prostacyclin and thromboxane A2 in older adults

Document Type

Article

Publication Date

1-1-1997

Abstract

Ten adult volunteers participated in 16 weeks of cardiovascular exercise training (EG) to determine the effects of training on resting prostacyclin (PGI ) and thromboxane A (TXA ). Six volunteers of similar age served as sedentary controls (CG). Blood was collected in tubes after training and eicosanoids were measured by standard I RIA methods. Over the 16 weeks of the study, PGI decreased 48% for EG and 33% for CG. There were no between-group differences for PGI values. No significant within-group changes in TXA were found, whereas between-group pretraining TXA values were significantly different. A time main effect for PGI may indicate a seasonal shift in this eicosanoid; however, the additional 15% decrease in PGI for EG may be due to a training-induced reduction in PGI substrate and/or endothelial sensitivity to agonists. The lack of within-group changes in TXA may be due to a combination of high platelet turnover and a training stimulus inadequate to alter platelet function. © 1997 Human Kinetics Publishers, Inc. 2 2 2 2 2 2 2 2 2 2 2 123

Publication Name

Journal of Aging and Physical Activity

Volume Number

5

First Page

59

Last Page

70

Issue Number

1

DOI

10.1123/japa.5.1.59

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