Title

Structure determination of BA0150, a putative polysaccharide deacetylase from Bacillus anthracis

Document Type

Article

Publication Date

1-1-2014

Abstract

Polysaccharide deacetylases are bacterial enzymes that catalyze the deacetylation of acetylated sugars on the membranes of Gram-positive bacteria, allowing them to be unrecognized by host immune systems. Inhibition of these enzymes would disrupt such pathogenic defensive mechanisms and therefore offers a promising route for the development of novel antibiotic therapeutics. Here, the first X-ray crystal structure of BA0150, a putative polysaccharide deacetylase from Bacillus anthracis, is reported to 2.0Å resolution. The overall structure maintains the conserved (α/β)8 fold that is characteristic of this family of enzymes. The lack of a catalytic metal ion and a distinctive metal-binding site, however, suggest that this enzyme is not a functional polysaccharide deacetylase. © 2014 International Union of Crystallography All rights reserved.

Publication Name

Acta Crystallographica Section F:Structural Biology Communications

Volume Number

70

First Page

156

Last Page

159

Issue Number

2

DOI

10.1107/S2053230X13034262

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