Title

Adaptation and Fitness Graphs

Document Type

Article

Publication Date

3-25-2015

Abstract

Understanding evolutionary processes is important in the study of medicine and agriculture. In many instances, the underlying cause for novel pathogens, pests, and antimicrobial drug resistance are complex evolutionary processes. Such processes may initially go unnoticed if the first mutations have moderate effects. However, the end result may be a radically altered organism. DNA sequencing and other laboratory techniques provide detailed information on systems involving several mutations and complex gene interactions. Making sense of such data is an important challenge in modern biology. Recent discrete approaches, including graphs and polytopes, have proved useful. The main focus of this chapter is fitness graphs, an elementary and yet effective approach to complex biological systems.

Publication Name

Algebraic and Discrete Mathematical Methods for Modern Biology

First Page

51

Last Page

64

DOI

10.1016/B978-0-12-801213-0.00003-4

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